Nonmyelinating Schwann cell
The nonmyelinating Schwann cells are a subgroup of the Schwann cells characterized by not forming myelin.[1]
The group of nonmyelinating Schwann cells includes the terminal Schwann cells, present at neuromuscular junctions, the Schwann cells of Remak fibers (also called Remak Schwann cells) and the Schwann cells associated to sensory structures, like tactile corpuscles and lamellar corpuscles.[1]
Remak Schwann cells[edit]
The Schwann cells of Remak fibers, or Remak Schwann cells (RSCs), are named after the German neurobiologist Robert Remak and are present in nerve fibers observed by him around 1838. In the peripheral nervous system, the Remak Schwann cells are more numerous than the myelinating Schwann cells.[1]
They provide metabolic support to neurons, among other functions, but as no specific genetic markers have been detailed (at least as of 2017), there is still a large gap in understanding their biology in separation of other Schwann cells.[2]
Terminal Schwann cells[edit]
Terminal Schwann cells (tSCs), also called perisynaptic Schwann cells,” and “teloglia", are nonmyelinating Schwann cells present at neuromuscular junctions. It is suggested that they might play a role in forming and maintaining synapses or modulating synaptic signalling.[1][3]
References[edit]
- ^ a b c d Griffin JW, Thompson WJ (November 2008). "Biology and pathology of nonmyelinating Schwann cells". Glia. 56 (14): 1518–1531. doi:10.1002/glia.20778. PMID 18803315.
- ^ Harty BL, Monk KR (December 2017). "Unwrapping the unappreciated: recent progress in Remak Schwann cell biology". Current Opinion in Neurobiology. 47: 131–137. doi:10.1016/j.conb.2017.10.003. PMC 5963510. PMID 29096241.
- ^ Feng Z, Ko CP (September 2008). "Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1". The Journal of Neuroscience. 28 (39): 9599–9609. doi:10.1523/JNEUROSCI.2589-08.2008. PMC 3844879. PMID 18815246.