DcuC family
| C4-dicarboxylate anaerobic carrier | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DcuC | ||||||||
| Pfam | PF03606 | ||||||||
| Pfam clan | CL0182 | ||||||||
| InterPro | IPR018385 | ||||||||
| TCDB | 9.B.50 | ||||||||
| |||||||||
The C4-dicarboxylate uptake C family or DcuC family (TC# 2.A.61) is a family of transmembrane ion transporters found in bacteria.[1] A representative list of proteins belonging to the DcuC family can be found in the Transporter Classification Database.
An anaerobic C4-dicarboxylate transporter (DcuC) of E. coli (TC# 2.A.61.1.1) has 14 putative transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalysing fumarate-succinate exchange and fumarate uptake.[2][3] DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates).[4][5]
The reactions probably catalyzed by the E. coli DcuC protein are:
- C4-dicarboxylate (out) + nH+ (out) → C4-dicarboxylate (in) + nH+ (in)
- C4-dicarboxylate1 (out) + C4-dicarboxylate2 (in) ⇌ C4-dicarboxylate1 (in) + C4-dicarboxylate2 (out).
See also[edit]
References[edit]
- ^ Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. ISSN 0006-3002. PMID 14643936.
- ^ Engel P, Kramer R, Unden G (June 1994). "Transport of C4-dicarboxylates by anaerobically grown Escherichia coli. Energetics and mechanism of exchange, uptake and efflux". Eur. J. Biochem. 222 (2): 605–14. doi:10.1111/j.1432-1033.1994.tb18903.x. PMID 8020497.
- ^ Zientz E, Janausch IG, Six S, Unden G (June 1999). "Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli". J. Bacteriol. 181 (12): 3716–20. doi:10.1128/JB.181.12.3716-3720.1999. PMC 93849. PMID 10368146.
- ^ Zientz E, Six S, Unden G (December 1996). "Identification of a third secondary carrier (DcuC) for anaerobic C4-dicarboxylate transport in Escherichia coli: roles of the three Dcu carriers in uptake and exchange". J. Bacteriol. 178 (24): 7241–7. doi:10.1128/jb.178.24.7241-7247.1996. PMC 178639. PMID 8955408.
- ^ "2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family". Transporter Classification Database. Retrieved 2016-03-04.
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